Hayden Panettiere shared a touching tribute to her late brother Jansen Panettiere to mark the second anniversary of his untimely pᴀssing at age 28.

‘This amazing human being touched the lives of so many. Especially mine,’ the 35-year-old Heroes alum wrote to her 828K Instagram followers on Wednesday.

‘The pain isn’t quantifiable. I pray you’re in a beautiful place J. That you’re at peace and that when all is said and done… I’ll see you again. Rest easy brother. You are so missed and beyond loved.’

The medical examiner reported that the graffiti artist pᴀssed away from cardiomegaly (an enlarged heart) coupled with aortic valve complications, and his body was buried at Kensico Cemetery in Valhalla, NY.

‘He was my only sibling, and it was my job to protect him. When I lost him, I felt like I lost half of my soul,’ Hayden lamented to People on September 18.

‘I will always be heartbroken about it. I will never be able to get over it. No matter how many years go by, I will never get over his loss.’

Hayden Panettiere shared a touching tribute to her late brother Jansen Panettiere to mark the second anniversary of his untimely pᴀssing at age 28 (throwback to a rafting trip)

The 35-year-old Heroes alum wrote to her 828K Instagram followers on Wednesday: ‘This amazing human being touched the lives of so many. Especially mine. The pain isn’t quantifiable. I pray you’re in a beautiful place J. That you’re at peace and that when all is said and done… I’ll see you again. Rest easy brother. You are so missed and beyond loved’

Panettiere added: ‘When something that mᴀssive has happened to you, you really learn to pick your fights and just not let the little things upset you. Because once something so horrific, so deep, so catastrophic happens in your life, there’s not much that can really rock you.’

The siblings co-starred in three films – Tiger Cruise (2004), Racing Stripes (2005), and The Forger (2012).

Jansen last portrayed Fizz in Christopher Broe and Basil Mironer’s 1999-set teen musical Bart Bagalzby and the Garbage Genie, which he sH๏τ back in 2021 but it only began streaming VOD on January 10.

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The curly-haired artist also guest-starred in episodes of Disney Channel’s Even Stevens, The CW’s Everybody Hates Chris, and AMC’s The Walking ᴅᴇᴀᴅ.

Hayden – who’s completed two rehab stints for addiction to opioids and alcohol – made more headlines last September for slurring her speech during interviews with People and TODAY.

Panettiere blamed her visible exhaustion on not sleeping for two days over her pet needing emergency surgery, writing on Instagram: ‘My rep stopped the interview early as it became obvious that I was fading – especially as the subject matter became heavier.’

The two-time Golden Globe nominee will detail her sobriety journey in her book Break Free: Addiction, Trauma, and How the Cheerleader Saved Herself – which Grand Central Publishing will release in early 2026.

On February 2, ᴅᴇᴀᴅline reported that Hayden just wrapped her role as grieving mother Sarah in Brandon Auman’s Rhode Island-set psychological thriller, Sleepwalker.

The medical examiner reported that the graffiti artist pᴀssed away from cardiomegaly (an enlarged heart) coupled with aortic valve complications, and his body was buried at Kensico Cemetery in Valhalla, NY

Hayden lamented to People on September 18: ‘He was my only sibling, and it was my job to protect him. When I lost him, I felt like I lost half of my soul’ (pictured in 2019)

Panettiere continued: ‘I will always be heartbroken about it. I will never be able to get over it. No matter how many years go by, I will never get over his loss’

She added: ‘When something that mᴀssive has happened to you, you really learn to pick your fights and just not let the little things upset you. Because once something so horrific, so deep, so catastrophic happens in your life, there’s not much that can really rock you’ (pictured in 2021)

The siblings co-starred in three films – Tiger Cruise (pictured in 2004), Racing Stripes (2005), and The Forger (2012)

Jansen last portrayed Fizz in Christopher Broe and Basil Mironer’s 1999-set teen musical Bart Bagalzby and the Garbage Genie, which he sH๏τ back in 2021 but it only began streaming VOD on January 10

Hayden – who’s completed two rehab stints for addiction to opioids and alcohol – made more headlines last September for slurring her speech during interviews with People and TODAY (pictured September 24)

Panettiere will detail her sobriety journey in her book Break Free: Addiction, Trauma, and How the Cheerleader Saved Herself – which Grand Central Publishing will release in early 2026 (pictured September 22) 

And last August, Panettiere was cast in the Furst Brothers’ upcoming survival flick A Breed Apart, which was described as a reimagining of the 2006 Wes Craven movie The Breed.

On the personal front, the Amber Alert producer-star lost custody of her 10-year-old daughter Kaya Evdokia Klitschko, who’s being cared for full-time by her ex-fiancé Wladimir Klitschko.

Hayden and the 48-year-old retired heavyweight boxer amicably ended their on/off nine-year relationship in 2018.